GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4925540 | 1 | rs4925540 | chr1:247214878 | OR2W3 | chr1:248031265-248060142:+ | -0.18 | -3.57 | 0.00039 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs4925540 | chr1:247214878 | TRIM58 | chr1:248020501-248043436:+ | -0.15 | -3.35 | 0.000879 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs683250 | 1 | rs492607 | chr11:83295311 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 3.92 | 9.97E-5 | Subcortical brain region volumes |
| THCA | cis | rs3767627 | 1 | rs4926400 | chr1:149931541 | FCGR1C | chr1:149369294-149378295:+ | -0.17 | -3.5 | 0.000504 | Height |
| THCA | cis | rs3767627 | 1 | rs4926400 | chr1:149931541 | SV2A | chr1:149874876-149889434:- | 0.16 | 3.35 | 0.000886 | Height |
| THCA | cis | rs4929949 | 1 | rs4929949 | chr11:8604593 | STK33 | chr11:8413418-8615775:- | 0.25 | 6.08 | 2.45E-9 | Body mass index |
| THCA | cis | rs4929949 | 1 | rs4929949 | chr11:8604593 | TRIM66 | chr11:8633586-8693413:- | 0.21 | 5.28 | 1.94E-7 | Body mass index |
| THCA | cis | rs4930103 | 1 | rs4929983 | chr11:2024579 | LOC100133545 | chr11:2004440-2011150:- | -0.16 | -3.74 | 0.00021 | DNA methylation (variation);DNA methylation (parent-of-origin) |
| THCA | cis | rs4930103 | 1 | rs4930103 | chr11:2024544 | LOC100133545 | chr11:2004440-2011150:- | -0.17 | -3.89 | 0.000117 | DNA methylation (variation);DNA methylation (parent-of-origin) |
| THCA | cis | rs3750965 | 1 | rs4930643 | chr11:68818936 | TPCN2 | chr11:68816350-68929907:+ | -0.15 | -3.63 | 0.000315 | Hair color |
| THCA | cis | rs7116495 | 1 | rs493065 | chr11:71796929 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.81 | 0.000158 | Severe influenza A (H1N1) infection |
| THCA | cis | rs4765219 | 1 | rs4930723 | chr12:124423600 | ZNF664 | chr12:124457670-124499967:+ | -0.18 | -5.03 | 7.04E-7 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4765219 | 1 | rs4930725 | chr12:124428162 | ZNF664 | chr12:124457670-124499967:+ | -0.17 | -4.8 | 2.16E-6 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4765219 | 1 | rs4930726 | chr12:124428331 | DNAH10 | chr12:124247042-124420265:+ | 0.18 | 3.77 | 0.000182 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4765219 | 1 | rs4930726 | chr12:124428331 | ZNF664 | chr12:124457670-124499967:+ | -0.17 | -4.91 | 1.27E-6 | Waist-to-hip ratio adjusted for body mass index |